Proposed Mathematical Model Of The Cyclic Relationship Between Estradiol And Endometriosis Lesions

Endometriosis is a disorder in which endometrial tissue grows on or outside the uterus. While endometriosis affects roughly 190 million females around the world, little research exists exploring both the causes of endometriosis and preventative treatment of progressive factors. One theory for endometriosis is an imbalance of estradiol, E2, and progesterone, P4, in the body. An elevated ratio of E2 to P4 can indicate the growth of endometriosis lesions, which are another source of E2 production. Such lesions disrupt regular E2 levels throughout the menstrual cycle, resulting in continuous endometrium growth. The relationship between E2 levels and lesion growth – and an increased ratio of E2 to P4 – was demonstrated using Margolskee et al.’s 2013 model of the menstrual cycle and Arbel´az-G´omez et al.’s 2022 model of endometrium growth. Periodic exogenous E2 suppression was shown to be an effective treatment for preventing excessive endometrial tissue volume in the presence of lesions.

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